KLM is the only airline that operates nonstop flights for this route. Tickets can also be purchased with Delta, or another member of the SkyTeam alliance.
There are 2 daily flights on Monday, Wednesday, Friday, and Saturday (departing 1:55 PM and 4:55 PM). There is 1 daily flight on Sunday, Tuesday, and Thursday, departing 1:55PM.
Options with stops include layovers in: New York City (JFK, EWR), Frankfurt (FRA), Istanbul (IST), Dublin (DUB), Dallas (DFW), Philadelphia (PHL), London (LHR, LGW), Paris (CDG), Rome (FCO), Washington, D.C. (IAD), Toronto (YYZ), Zurich (ZRH), Munich (MUC), Vienna (VIE), and others.